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Evidence is increasing that most addiction without exception is related to difficulty with the brain's reward center, particularly the mesolimbic system. This part of the problem regulates reward responses in getting food and sex, plus in nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both when they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008).
Using two separate drugs to shed weight can be very effective you can find combinations before the FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you should err on the side of caution and allow FDA do its job and demand some research be done so the public recognizes the side effects and risks of the medications before we drive them. Keep in mind that drug companies are in business to generate money and that they would say almost anything to keep people on their medications.
Researchers discovered that participants using this drug for the year, lost weight within four weeks and have kept the extra weight off during the entire 56 weeks with the study. Contrave is a combination with the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs that are made up of multiple active ingredient, which can make them far better and safer.
Combo-pilling is the newest fad or even better the newest to come under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular could be the fact that as of right now there aren't any long term prescription weight loss supplements that have been approved by the FDA besides orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be licensed by the FDA.
Seizures can be a side effect with Contrave and shouldn't be taken in people who have seizure disorders. The drug could also raise hypertension and heartbeat, and really should not be used in individuals with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug.
The FDA also warned that Contrave can raise blood pressure level and pulse rate and must not be used in patients with uncontrolled high blood pressure level, and also by a person with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients using a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert physicians and patients to the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stop smoking.
'The intent of the bill would be to give police force and district attorneys a power tool to address illicit drug use among pregnant women through treatment programs," Tennessee governor Bill Haslam said.